PaddyPower Pre-Match Odds: Liverpool 7/5, Draw 13/5, Barcelona 7/4*
The chances of the Reds reaching the final of Europe's premier club competition for the second-successive year seem slim after they lost last week's first leg at the Nou Camp 3-0.
Lionel Messi was the star of the show that night, grabbing a brace that included a sublime free-kick that brought up his 600th goal for the club and that all came after former Liverpool striker Luis Suarez had opened the scoring during the first half.
If Liverpool's task wasn't already hard enough, the news that they will be without forwards Mohamed Salah and Roberto Firmino for Tuesday's match will come as a further blow.
Salah sustained a head injury during the Reds' hard-fought 3-2 victory over Newcastle in the Premier League on Saturday, while Firmino remains sidelined with the muscle issue that limited him to a substitute appearance during last week's first leg.
Midfielder Naby Keita has also been ruled out with an adductor injury, which leaves the resources at Jurgen Klopp's disposal looking a little stretched.
Tiredness could also be a factor for Liverpool, who were pushed all the way by Newcastle on Saturday, while they also have their pivotal final match of the Premier League season against Wolves to come on Sunday.
Barcelona have faced no such worries, as they wrapped up the La Liga title last month and coach Ernesto Valverde even had the luxury of being able to rotate his entire starting XI for Saturday's 2-0 loss at Celta Vigo.
Ousmane Dembele did pick up a hamstring injury in that match and will miss Tuesday's contest as a result, but that should not be too much of a concern for Barca, who still boast the firepower of Messi, Suarez and another former Liverpool player in Philippe Coutinho.
Liverpool welcome Barcelona to Anfield as they look to overturn a three goal deficit against the Catalans giants.
Three-nil down at half time of a big Champions League game – this is familiar territory for Liverpool fans. However, unlike that famous night in Istanbul, the situation now looks a lot bleaker.
With top scorers Mohamed Salah and Roberto Firmino both out of contention for Tuesday’s clash, the outright odds on the Reds have taken a hit.
Jurgen Klopp’s side are expected to go on the attack from the first minute which means Barcelona may have opportunities to hit the English side on the counter.
With that in mind, a home win and both teams to score is the recommended bet in this game at the current price of 3/1.
There are of course a number of other valuable markets ahead of this clash. For instance, Lionel Messi to score anytime is currently priced at even money with most bookmakers. With the Argentinian in scintillating form, this may be another smart way to bet.
The total goals market also provides some value. Two or three goals to be scored in this game has been priced at 11/10. This exact bet landed last week with the Catalan side running out 3-0 winners.
Liverpool to win and both teams to score – 3/1 PaddyPower*
*prices correct at time of writing and are subject to change
**Selected markets only. Pre-match singles only. Max free bet £/€10. T&Cs apply.