The Seagulls have dragged themselves into a relegation battle in recent weeks, with Chris Hughton's men now just three points above the drop zone.
Cardiff continue to fight with Brighton for a place in the Premier League next season and Hughton's men may need a slice of luck this weekend.
They battled hard in midweek against Tottenham, before Christian Eriksen's strike saw them leave London with nothing.
Brighton have now gone six league games without finding the net and the fixture with Newcastle gives them a chance to pick up points, especially with Arsenal and Manchester City still to come.
Hughton will have Anthony Knockaert available for Saturday's clash after he completed his three-match suspension against Bournemouth on April 13.
Netherlands midfielder Davy Propper remains sidelined with a hamstring problem while Rafa Benitez will also have injury worries of his own.
Newcastle midfielder Miguel Almiron (hamstring) will miss Saturday's trip to Brighton, as will skipper Jamaal Lascelles after being laid low by illness this week.
The Magpies confirmed their top-flight status last week after last week's win over Southampton.
The Seagulls are looking to complete the league double over Newcastle for the first time since the 1978-79 second tier campaign.
Newcastle United will be aiming to win a third straight game when they take on relegation threatened Brighton this Saturday night.
Victories over Leicester and Southampton have pushed the Magpies into 13th place and more importantly, secured the clubs Premier League status for next season.
For Brighton, the job of securing top tier football is far from over. The Seagulls are only three points clear of Cardiff City with the same number of games to go.
A win for Chris Houghton’s side is critical if they are to survive. The bookmakers certainly have their back in this game making Brighton the 13/10 favourites to win.
When the bookmakers were signing off the prices they perhaps forgot to take a look at the form table. Brighton are without a win in seven games which includes one draw and six defeats.
Newcastle, on the other hand, have only suffered three defeats in their last ten Premier League fixtures.
The one thing in Brighton’s favour is the head to head record against Newcastle. The south coast side are unbeaten in their last three encounters – two of which they have won.
Despite that, the recommendation is to back the away side at an attractive price of 23/10. For those looking for more value, Newcastle to win by a margin of one goal is currently priced at 4/1.
Newcastle to win – 23/10 PaddyPower