Paddy Power pre-match odds: Arsenal 4/9, Draw 7/2, Crystal Palace 11/2*
The Gunners are in a real battle to finish in the Champions League positions but they head into the contest on the back of a 1-0 Europa League victory in Napoli on Thursday, a result which sent Unai Emery's men into the semi-finals.
Arsenal have won their last three games in all competitions - all of those coming with clean sheets - while they have come out victorious in their last eight home matches.
Wales international Aaron Ramsey has been ruled out of the game after picking up a hamstring injury in the win in Italy but the midfielder is hoping to return before the end of the season.
Centre-back Sokratis is also missing as he serves the final game of his two-match suspension, while the midfield duo of Granit Xhaka and Denis Suarez are being assessed as they struggle with hip and groin issues respectively.
Right-back Hector Bellerin and fellow defender Rob Holding are long-term absentees as they continue to recover from knee injuries while forward Danny Welbeck has only just started on-field rehabilitation following an injury to his right ankle.
Palace's survival is almost assured with eight points the gap to 18th-placed Cardiff City and the Eagles will be looking to bounce back to winning ways after the 3-1 loss to Manchester City last time out.
Roy Hodgson's men have won three of their last four league matches away from home but they have never picked up a win at the Emirates in the six times they have visited.
Palace will be without Jeffrey Schlupp, who will miss the remainder of the season with an ankle injury, Mamadou Sakho and James Tomkins.
*odds correct at time of posting and are subject to change