After booking their place in the Champions League semi-finals in dramatic fashion against Manchester City last midweek, Spurs were brought back down to earth after losing 1-0 to the same opposition in the league on Saturday.
That result leaves Spurs' top-four hopes hanging in the balance, but they will fancy their chances of maintaining their perfect record at the Tottenham Hotspur Stadium on Tuesday, as they have won all three of their matches at the venue and are yet to concede a goal.
Brighton, by contrast, have failed to win or score in any of their last five Premier League games, a run that has seen them slip just a place and three points above the bottom three.
Relegation remains a distinct possibility for Chris Hughton's side, although they did end a five-game losing streak across all competitions by earning a goalless draw against Wolves at Molineux on Saturday.
Tottenham should be able to welcome captain Hugo Lloris back in goal after he sat out Saturday's defeat to City with a muscular issue, although top scorer Harry Kane remains sidelined with an ankle problem.
Brighton will assess the fitness of Davy Propper and Bruno, who were both substituted during the draw with Wolves, while Anthony Knockaert will serve the final match of his three-game ban.