Manchester City's 2-0 victory at home to Cardiff City on Wednesday night moved the defending champions into first place, putting the pressure back on second-place Liverpool, who are one point behind the table-toppers.
The Reds are on a four-game winning run heading into the clash at St Mary's after edging past Tottenham Hotspur 2-1 last time out and they title-challengers are unbeaten in their last six matches away from home in all competitions.
In a huge positive for Liverpool, Jurgen Klopp has confirmed Netherlands international Virgil van Dijk has recovered from the knock he sustained against Spurs and is available for selection.
Barring midfielder Alex Oxlade-Chamberlain and defender Joe Gomez, the visitors have no injury concerns ahead of the contest and will be feeling confident of picking up all three points.
Southampton are still battling against relegation, with five points the gap between themselves and 18th-place Cardiff, but the Saints are in great form after winning three of their last four matches.
Victories over Fulham, Spurs and Brighton have put Ralph Hasenhuttl's men closer to safety and home form has been crucial to the upturn in results, with just one league defeat suffered from the last five at St Mary's.
The Saints will be without striker Danny Ings, who is ineligible to play against his parent club, but defender Jannik Vestergaard and forward Shane Long have both returned to training.
Liverpool are unbeaten in the last four meetings with Southampton, winning three and drawing one.
The pressure is building on Liverpool as they look to keep pace with Manchester City. Their chase for the title continues this Friday when they travel south to take on Southampton.
Jurgen Klopp’s side have been in good form recently and have enjoyed a run of four straight wins in all competitions. In their last outing, the Reds pulled off a last gasp victory over Tottenham which sent the Anfield crowd into raptures.
Southampton also have a lot to play for in this upcoming fixture with Saints only five points above 18thplaced Cardiff City.
Just like their opponents, Ralph Hassenhuttl’s side are in good form having won three of their last four Premier League games.
The pre-match odds present a big gulf between both clubs. This is perhaps caused not only by the league standings but also the head to head record.
Liverpool have won three straight encounters against Southampton, scoring eight goals and conceding none in the process. In fact, Saints haven’t scored a goal against the Reds in over 450 minutes of Premier League football.
The recommendation in this game is to back the visitors and both teams to score. Liverpool haven’t kept a clean sheet since their 0-0 draw with Everton at the beginning of March. Meanwhile, Southampton have managed to net at least one goal in each of their last four games.
What’s more, with Saints fighting for their Premier League survival, this is the perfect time for them to break their goalless streak against Liverpool.
Liverpool to win and both teams to score – 9/4 888Sport*
*prices correct at time of posting and are subject to change
**Your bet will be paid out in full if your team is winning by 2 goals at any stage in the match regardless if your selection goes on to draw or lose the game. Applies to all Premier League, La Liga and Champions League games (pre-match singles in the Win-Draw-Win market only) until 1st June 2019. T&Cs apply.