United will be desperate to bounce back from a recent run of form that has seen them lose six of their last eight games across all competitions, a run that includes Sunday’s 4-0 hammering at Everton.
City, by contrast, have won 10 Premier League matches on the spin since losing at Newcastle at the end of January, and they can move back to the top of the Premier League standings if they secure all three points at the home of their city rivals.
That may be easier said than done, however, as, despite their poor recent form, United are actually unbeaten in their last 14 top-flight matches on home soil, winning nine of those games, with Tottenham being the last team to claim all three points at Old Trafford back in August.
However, if any team knows how to win at the Theatre of Dreams it is City, who have emerged victorious on five of their last seven league trips to Old Trafford, including a 2-1 victory on their most recent visit last season.
United boss Ole Gunnar Solskjaer was involved in many Manchester derbies as a player, but this will be his first one as a manager and he is expected to be boosted by the return of midfielder Ander Herrera, who has been sidelined for the last four weeks with a thigh injury.
Luke Shaw is also available following a domestic suspension, while Solskjaer may look to make a number of changes to the team that struggled so badly against Everton.
The big team news for City is that Kevin de Bruyne will miss Wednesday's match with the muscular injury he picked up against Tottenham at the weekend.
The Belgian could, however, return for Sunday's trip to Turf Moor to take on Burnley.
Manchester United have been priced at a massive 11/2 ahead of their clash with neighbors Manchester City. The question is whether it’s worth taking?
PaddyPower Pre-Match Odds: Man Utd 11/2, Draw 7/2, Man City 4/9
What’s going on with Manchester United? Ole Gunnar Solskjaer’s men will be hoping to find an answer as quick as they can ahead of this upcoming do or die clash with rivals City.
United are heading into this game on the back of two straight defeats. A 3-0 loss to Barcelona in the Champions League was followed by a 4-0 whopping at the hands of Everton.
Perhaps what’s more concerning is the fact that United have only managed two goals in four games - at the same time conceding nine.
Looking at Manchester City, theoretically they should clubber their local rivals with time to spare. City are on a three-match winning run and have suffered just one defeat in 18 games across all competitions.
With that in mind, the recommendation is to back the visitors. However, City alone don’t provide many attractive prices. In order to find value, we recommend to back a City win by a margin of two goals.
This bet is currently priced at 10/3 which makes far better reading than the outright price of 4/9.
Man City to win by a margin of two goals – 10/3 bet365